Comparison of efficacy and tolerability of aceclofenac and diclofenac in osteoarthritis of knee joint.
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Date
2015-07
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Abstract
Background: Osteoarthritis is a slowly progressive disorder
associated with a hyaline cartilage loss. Non-steroidal antiinflammatory
drugs play a pertinent role in management of
osteoarthritis.
Objectives: The study was carried out for the comparison of efficacy
and tolerability of Aceclofenac and Diclofenac in patients of
osteoarthritis of knee joint.
Material and Methods: It is a randomised parallel group double
blinded study. The study included 60 patients of confirmed
osteoarthritis of knee joint, 30 patients were given Aceclofenac and
30 patients were given Diclofenac after food for 8 weeks and the
patients were evaluated and compared statistically for pain
intensity by VAS Score, Joint tenderness, Swelling, Erythema, Pain
on movement, Functional capacity and Overall Assessment on
LIKERT Scale.
Results: Both the drugs caused marked improvements in the
parameters of - Pain intensity, Joint tenderness, Swelling, Erythema,
Pain on movement of OA knee joint but there was increased
improvement in all the parameters with aceclofenac.
Conclusion: Aceclofenac is the NSAID of choice in the osteoarthritis
of knee joint as compare to Diclofenac.
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Keywords
NSAID, osteoarthritis, aceclofenac, diclofenac, joint
Citation
Sehgal A, Sehgal VK, Singh R. Comparison of efficacy and tolerability of aceclofenac and diclofenac in osteoarthritis of knee joint. International Journal of Medical and Dental Sciences. 2015 July; 4(2): 745-750.