Use of lycopene in the management of oral submucous fibrosis: a clinical study.
Loading...
Date
2016-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Oral Submucous Fibrosis is a potentially malignant
disorder well known for its chronic and resistant nature. The
conservative drug treatment that is currently available for this
disorder is clearly inadequate.
Objective: The study was done to evaluate the efficacy of oral
lycopene therapy when used in combination with conventional
intralesional steroid therapy in the management of oral
submucous fibrosis.
Methods: Thirty patients with oral submucous fibrosis (grade III
and IV) were included and randomly divided into 2 groups
consisting of 15 each: Group A (oral lycopene with biweekly
intralesional steroids and hyaluronidase), Group B (biweekly
intralesional steroids and hyaluronidase alone). Mouth opening
and burning sensation were recorded from baseline to 6 weeks.
Cases were followed up to 3 and 6 months.
Results: We observed a complete relief of burning sensation in all
patients of both the groups, There was significant increase in
mouth opening among both groups. The patients in the group B
had increased moth opening than the group A patients.The results
were statistically significant
Conclusion: Lycopene in combination with intralesional steroids
and Hyaluronidase, is highly efficacious in improving the mouth opening and reducing other symptoms in patients
with Oral Submucous Fibrosis. No side effects were reported with its usage.
Description
Keywords
OSMF, lycopene, mouth opening, burning sensation, steroids
Citation
Kaur H, Singh A, Goyal S. Use of lycopene in the management of oral submucous fibrosis: a clinical study. International Journal of Medical and Dental Sciences. 2016 July; 5(2): 1229-1235.