Effificacy of autologous platelet-rich plasma combined with fractional ablative carbon dioxide resurfacing laser in treatment of facial atrophic acne scars: A split-face randomized clinical trial.
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Date
2016-03
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Abstract
Background: Autologous platelet-rich plasma has recently attracted signifi cant attention
throughout the medical fi eld for its wound-healing ability. Aims: This study was conducted to
investigate the potential of platelet-rich plasma combined with fractional laser therapy in the
treatment of acne scarring. Methods: Sixteen patients (12 women and 4 men) who underwent
split-face therapy were analyzed in this study. They received ablative fractional carbon dioxide
laser combined with intradermal platelet-rich plasma treatment on one half of their face and
ablative fractional carbon dioxide laser with intradermal normal saline on the other half. The
injections were administered immediately after laser therapy. The treatment sessions were
repeated after an interval of one month. The clinical response was assessed based on patient
satisfaction and the objective evaluation of serial photographs by two blinded dermatologists
at baseline, 1 month after the fi rst treatment session and 4 months after the second. The
adverse effects including erythema and edema were scored by participants on days 0, 2, 4,
6, 8, 15 and 30 after each session. Results: Overall clinical improvement of acne scars was
higher on the platelet-rich plasma-fractional carbon dioxide laser treated side but the difference
was not statistically signifi cant either 1 month after the fi rst treatment session (P = 0.15) or
4 months after the second (P = 0.23). In addition, adverse effects (erythema and edema)
on the platelet-rich plasma-fractional carbon dioxide laser-treated side were more severe
and of longer duration. Limitations: Small sample size, absence of all skin phototypes
within the study group and lack of objective methods for the evaluation of response to
treatment and adverse effects were the limitations. Conclusion: This study demonstrated
that adding platelet-rich plasma to fractional carbon dioxide laser treatment did not produce
any statistically signifi cant synergistic effects and also resulted in more severe side effects
and longer downtime.
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Keywords
Acne, fractional carbon dioxide laser resurfacing, laser ablation, platelet-rich plasma, scar
Citation
Faghihi Gita, Keyvan Shima, Asilian Ali, Nouraei Saeid, Behfar Shadi, Nilforoushzadeh Mohamad Ali. Effificacy of autologous platelet-rich plasma combined with fractional ablative carbon dioxide resurfacing laser in treatment of facial atrophic acne scars: A split-face randomized clinical trial. Indian Journal of Dermatology, Venereology and Leprology. 2016 Mar-Apr; 82(2): 162-168.