Effect of pinacidil on the contractile response of cyclophosphamide-treated rat vas deferens.
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1999-03-18
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Effect of pinacidil, a K+ channel opener, was studied on contractility of cyclophosphamide-treated rat vas deferens. The mean IC50 value of pinacidil against 1 mmol barium chloride induced rhythmic contractions and 40 mmol potassium chloride induced tonic contractions was significantly (P < 0.01 and P < 0.001, respectively) increased in the cyclophosphamide treated group as compared to the control. The mean EC50 value of norepinephrine (NE) in the presence of pinacidil (10(-6) mol) was significantly (P < 0.001) increased in the cyclophosphamide treated group. These findings indicate that the responsiveness of rat vas deferens smooth muscle to pinacidil is reduced following cyclophosphamide treatment.
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Reddy AG, Prakash VR, Tripathi HC, Tandan SK. Effect of pinacidil on the contractile response of cyclophosphamide-treated rat vas deferens. Indian Journal of Medical Research. 1999 Mar; 109(): 115-8