A Retrospective Cohort Study on Protective Efficacy of Intrapartum Nevirapine Prophylaxis to Prevent Parent to Child Transmission of Human Immunodeficiency Virus in West Bengal.
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Date
2016-09
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Abstract
Background: : In Prevention of Parent to Child Transmission (PPTCT) program in India, single dose Nevirapine was used
for prevention of intrapartum transmission of HIV, but the protective efficacy of this regimen in Indian population is not
beyond question. Objective: To analyze the protective efficacy of single dose Nevirapine prophylaxis in preventing mother
to child transmission of HIV and comparing the effect of Nevirapine prophylaxis in different types of infant feeding
practices and modes of delivery. Methods: A retrospective cohort study was carried out through analysis of secondary
data during October 2010 to September 2011 from 16 Integrated Counseling and Testing Centers (ICTCs) having DNAPCR
(Polymerase Chain Reaction) collection facility in West Bengal among 224 babies born of HIV infected mothers, 168
unexposed (covered with intrapartum Nevirapine) and 56 exposed (not covered with intrapartum Nevirapine) to risk of
transmission. HIV reactivity in babies was confirmed by DNA PCR of Dry Blood spot from 6 weeks age onwards. Data was
entered and analyzed using Epi Info version 3.5.1 and Statistical Package for Social Sciences software version (SPSS
16.0). Results: About 10.12% of those received Nevirapine were found HIV reactive compared to 26.79% of those who did
not. Overall Relative Risk of non coverage of Nevirapine for vertical transmission of HIV was 2.65 (95% CI : 1.42 – 4.95).
Overall Attributable Risk was 62.22%. Conclusion: Since in 62.2% cases vertical transmission of HIV was prevented,
additional regimen may be thought of for rest 37.8% cases.
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Keywords
HIV, Intrapartum transmission, Nevirapine
Citation
Chakraborty Debjit, Ganguly Suman, Pramanick Swati, Bera Satyajit, Basu Mausumi, Misra Raghunath. A Retrospective Cohort Study on Protective Efficacy of Intrapartum Nevirapine Prophylaxis to Prevent Parent to Child Transmission of Human Immunodeficiency Virus in West Bengal. Annals of International Medical and Dental Research. 2016 Sept-Oct; 2(5): 1-5.