Pre-emptive Use of Oral Pregabalin Attenuates the Pressor Response of Laryngoscopy and Endotracheal Intubation: A Double Blind Randomized Placebo Controlled Study.
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Date
2016-05
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Abstract
Background: Laryngoscopy and intubation may cause undesirable increase in blood pressure and heart rate. The aim of
the present study was to investigate the effect of Pregabalin premedication on hemodynamic responses to laryngoscopy
and intubation. Methods: Sixty ASA physical status I or II patients undergoing elective surgery under general anesthesia
were randomly allocated into two equal groups who received either oral Pregabalin 150 mg (Group PB)or placebo (Group
PL)1 hour prior to surgery. Heart rate, Systolic, Diastolic and Mean arterial blood pressures were recorded preoperative, at
laryngoscopy and 0,1,3,5 and 10 minutes after tracheal intubation. Results: Demographic data and base-line values for
Heart rate, Systolic, Diastolic and Mean arterial blood pressures were comparable between groups. During laryngoscopy
and intubation there was significant attenuation of SBP, DBP and MBP in PB group as compared to PL group. Although
increase in heart rate was less in pregabalin group during laryngoscopy and intubation but it was not statistically significant.
Conclusion: In the present study design, oral Pregabalin premedication at a dose of 150 mg one hour prior to surgery
attenuates pressor response associated with laryngoscopy and endotracheal intubation but not the tachycardia
significantly.
Description
Keywords
Haemodynamic response, Intubation, Laryngoscopy, Pregabalin
Citation
Bhandari Geeta, Mitra Subhro, Shahi Kedar Nath, Rani Anshu, Chauhan Aditya. Pre-emptive Use of Oral Pregabalin Attenuates the Pressor Response of Laryngoscopy and Endotracheal Intubation: A Double Blind Randomized Placebo Controlled Study. Annals of International Medical and Dental Research. 2016 May-June; 2(3): 110-114.