Inhibition of Cancer Cells Line by Biosurfactant Produced from Leuconostocmesenteroidesssp Cremoris.
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Date
2016-07
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Abstract
Objective: This brief research was initiated to search for cytotoxic effect of bio
surfactant produced by Leuconostocmesenteroidesssp. cremorisisolated from raw
cow’s milk.
Methods: Extraction of extracellular bio sufactant was completed and partially purified
by cold acetone precipitation, bio surfactant were tested against two cell lines, AMN3
(cancer cell line of mice mammary gland) and REF (noon cancerous normal cell line
transformed) specifically regarding cell viability and proliferation.
Results: Bio surfactant was found to decrease viability of AMN3 cancer cell line
studied at concentrations 1:3,2:2 and 1:3 V/V (biosurfactant: free serum media), the
inhibition percentage were 56.4%, 56.8% and 51.8% respectively, without affecting
normal fibroblasts growth.
Conclusion: The results gathered in this work are very promising regarding the bio
surfactant potential for cancer treatment and encourage further work with other cell
lines.
Description
Keywords
Cancer cell line, biosurfactant, Leuconostocmesenteroide
Citation
Salman Jehan Abdul Sattar, Marjani Mohammed F Al, Ghani Zaynab Saad Abdul. Inhibition of Cancer Cells Line by Biosurfactant Produced from Leuconostocmesenteroidesssp Cremoris. Acta Medica International. 2016 Jul-Dec; 3(2): 121-125.