Insulin-like Growth Factor Binding Protein-1/ alpha-fetoprotein versus Placental alpha microglobulin-1 for diagnosis of premature fetal membranes rupture.
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Date
2016-01
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Abstract
Objectives: To compare insulin-like growth factor binding protein-1/alpha-fetoprotein
(IGFBP-1/AFP) to placental alpha microglobulin-1 (PAMG-1) for diagnosis of
premature fetal membranes rupture (PROM).
Methods: 220 pregnant women ≥ 37 and < 39 weeks` gestation studied and classified
into two groups; study group (PROM) and control group (no PROM). Examination
of the studied women followed by abdominal ultrasound (TAS) and sterile vaginal
speculum examination to visualize amniotic fluid leaking and for collection of samples
for fern, nitrazine, AmniSure® and AmnioQuick® Duo+ tests on admission.
Results: The sensitivity and specificity of AmnioQuick® Duo+ test to detect PROM
was 93.6% and 86.4%; respectively compared to 95.5% and 89.1%; respectively for
AmniSure® test, 72.7% and 80.9%; respectively for fern test and 76.4% and 83.6%;
respectively for nitrazine test. PPV, NPV and accuracy of AmnioQuick® Duo+ test to
detect PROM were 87.3%, 93.1% and 90%; respectively compared to 89.7, 95.1% and
92.3%; respectively for AmniSure® test, 79.2%, 74.8% and 76.8%; respectively for fern
test and 82.4%, 77.97% and 80%; respectively for nitrazine test. AmnioQuick® Duo+
and AmniSure® tests had higher sensitivity, specificity, predictive values and accuracy
to detect PROM compared to conventional diagnostic tests.
Conclusion: AmnioQuick® Duo+ test for detection of IGFBP-1/AFP was rapid, accurate
bedside test better than the individual conventional diagnostic tests and has same
accuracy and performance like AmniSure® test.
Description
Keywords
IGFBP-1, AFP, PAMG-1, PROM
Citation
Abdelazim Ibrahim A, Al-Sherbeeny Mohammed M, Ibrahim Mohamed E M, Fahmy Ahmed A, Rabei Noha H, Khalifa Amr A Aziz. Insulin-like Growth Factor Binding Protein-1/ alpha-fetoprotein versus Placental alpha microglobulin-1 for diagnosis of premature fetal membranes rupture. Acta Medica International. 2016 Jan-June; 3(1): 69-74.