Outcomes of GnRH Agonist and GnRH Antagonist Regimens for IVF in Women Aged up to 40.
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Date
2016-01
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Abstract
Objective: To compare outcomes among good-prognosis patients undergoing in vitro
fertilization and intracytoplasmic sperm injection followed by embryo transfer (IVF/
ICSI-ET) in GnRH-agonist (GnRH-a) and GnRH-antagonist (GnRH-ant) regimens.
Methods: Retrospective analysis of 434 IVF/ICSI-ET cycles performed in a private
center, in women aged up to 40: GnRH-a (n = 291) and GnRH-ant (n = 143). Pregestational,
gestational and perinatal outcomes were evaluated. Statistical analysis was
performed by unpaired t-test, Mann-Whitney test and Fisher’s exact test. Significance
was set at p < 0.05.
Results: GnRH-a regimen was associated with higher amounts of total oocytes (10.7 ±
5.7 vs 9.3 ± 5.7, p < 0.001), mature oocytes (8.2 ± 4,5 vs 6.8 ± 4.4, p < 0.001) and good
quality embryos transferred (1.7 ± 0.8 vs 1.5 ± 0.9; p < 0.05). Rates of fertilization,
embryo implantation and live births were also higher in GnRH-a (72.8%, 27.6% and
48.8%, respectively) compared to GnRH-ant (65.3%, 14.7% and 26.6%, respectively;
p < 0.0001). There were no significant differences between rates of preterm delivery
or low birth weight, comparing the two groups.
Conclusion: Our results suggest that the long GnRH-a regimen is the one that
offers the best reproductive outcomes among in women aged up to 40 undergoing
IVF/ICSI-ET.
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Keywords
GnRH agonist, GnRH antagonist, IVF, ICSI, Reproductive outcomes
Citation
Jordão Érika Vieira de Souza, Nakagawa Hitomi Miura, Estrela Flavielly Souza, Morais Raiene Barbosa de, Gomes-Sobrinho David Barreira, Carvalho Bruno Ramalho de. Outcomes of GnRH Agonist and GnRH Antagonist Regimens for IVF in Women Aged up to 40. Acta Medica International. 2016 Jan-June; 3(1): 46-49.