Strategy Planning for Shortening the List of the Metabolic Syndrome Candidate Genes.
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Date
2015-07
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Abstract
Most diseases involve many genes in complex interactions, in addition to environmental influences. The genetic susceptibility to
a particular disease due to the presence of one or more gene mutations, and/or a combination of alleles need not necessarily be
abnormal. Understanding genetic predisposition to disease and knowledge of lifestyle modifications that either exacerbates the
condition or that lessen the potential for diseases is necessary for the societies to make informed choices. The aim of this narrative
review is to identify an optimal candidate gene and its single nucleotide polymorphism in metabolic syndrome. The prevalence of
non-communicable disorders such as metabolic syndrome (MetS) is high in developing countries such as Iran. The Tehran Lipid and
Glucose Study (TLGS) was one of the first studies reporting this high incidence. The present review aims to discover the genetic variant
reported in association with MetS. The database for genotypes and phenotypes (dbGaP) and the database for genetic associations
and human genome (HuGE navigator) were utilized in order to search for genes and their corresponding polymorphisms related
to MetS. Additionally, an electronic literature search for other Iranian studies and the genetic aspect of TLGS was completed using
PubMed. The results distinguished six of the most important genetic regions found to have strong association with MetS.
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Keywords
Tehran Lipid and Glucose Study, Metabolic syndrome, Genetic, Iran
Citation
Daneshpour M S. Strategy Planning for Shortening the List of the Metabolic Syndrome Candidate Genes. Acta Medica International. 2015 July-Dec; 2(2): 135-142.