MTHFR Gene (C677t) Polymorphism in Ischemic Stroke, its Subtypes and Hemorrhagic Stroke in a South Indian Population.
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Date
2015-07
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Abstract
Objective: We investigated the association of MTHFR C677T polymorphism with ischemic stroke, its subtypes and hemorrhagic stroke
in a South Indian Population from Andhra Pradesh. Methods: Six hundred and twenty ischemic stroke patients, 220 hemorrhagic
stroke patients and 620 age and sex matched healthy controls, were included in the present study. The polymorphism was determined
using PCR-RFLP technique. Results: The strength of association between genotypes and stroke types was measured by the odds ratio
with 95% confidence interval and chi-squared analysis. We found significant association of the CT genotype with ischemic stroke
as well as haemorrhagic stroke (p<0.05). Further, evaluating the association of this polymorphism with stroke subtypes, we found
significant association with intracranial large artery (p<0.05), lacunar stroke (p<0.05) and undetermined etiology (p<0.05). However,
there was no significant difference in genotypic or allelic frequencies between ischemic and hemorrhagic strokes. Conclusion: Our
study suggests that MTHFR (C677T) is an important risk factor for ischemic stroke, its subtypes and hemorrhagic stroke in the South
Indians from Andhra Pradesh but it cannot help in distinguishing between the two types of stroke.
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Keywords
MTHFR, C677T polymorphism, Ischemic stroke, Hemorrhagic stroke
Citation
Das Satrupa, Roy Sitara, Kaul Subhash, Jyothy Akka, Munshi Anjana. MTHFR Gene (C677t) Polymorphism in Ischemic Stroke, its Subtypes and Hemorrhagic Stroke in a South Indian Population. Acta Medica International. 2015 July-Dec; 2(2): 28-33.