In Vitro Comparison Of Generic And Branded Formulations Of Ceftazidime Using Standard Strain Of Pseudomonas.
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Date
2016-03
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Abstract
Background& Objective: Use of generic medicines has been increasing in recent years as a cost saving
measure in health care provision. But, there is an uncertainty about whether the quality of a generic medicine is
equal to, greater than or less than its equivalent brand-name drug. Its quality must be evaluated in vitro and in vivo
in order to confirm their suitability for therapeutic use. Here, we have done in vitro comparison of generic and brand
formulation of ceftazidime against pseudomonas standard strain (ATCC 27853). Methodology: One generic and three
brands of ceftazidime were selected for in vitro comparison. Microbiological assays were used to establish the
Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) against pseudomonas
standard strain (ATCC 27853) according CLSI (Clinical Laboratory Standard Institutes) guidelines. Results: The MIC
values of the ceftazidime samples evaluated (Brand and generics) were the same for pseudomonas standard strain
tested, indicating that all products behaved similarly. The MBC values were very similar for all samples. Overall,
therefore, the results showed no significant differences among samples. Conclusion: Reference method MIC and
MBC testing of ceftazidime against pseudomonas has demonstrated no significant difference in in vitro activity
between generic and brand products.
Description
Keywords
Ceftazidime, Pseudomonas, Generic drug, Brand drug, MIC, MBC
Citation
Tank Nitishkumar D, Bhansali Nishant B, Karelia Bharti N. In Vitro Comparison Of Generic And Branded Formulations Of Ceftazidime Using Standard Strain Of Pseudomonas. National Journal of Integrated Research in Medicine. 2016 Mar-Apr; 7(2): 31-36.