Recent Advances and Future Prospects of Phthalimide Derivatives.
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Date
2016-03
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Abstract
Among bicyclic non-aromatic nitrogen heterocycles, phthalimides are an interesting class of compounds with a large range of applications. Phthalimide contains an imide functional group and may be considered as nitrogen analogues of anhydrides or as diacyl derivatives of ammonia. They are lipophilic and neutral compounds and can therefore easily cross biological membranes in vivo and showing different pharmacological activities. In the present work compounds containing phthalimide subunit have been described as a scaffold to design new prototypes drug candidates with different biological activities and are used in different diseases as, for example AIDS, tumor, diabetes, multiple myeloma, convulsion, inflammation, pain, bacterial infection among others.
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Keywords
Phthalimide derivatives, imide, biological activity
Citation
Kushwaha Neelottama, Kaushik Darpan. Recent Advances and Future Prospects of Phthalimide Derivatives. Journal of Applied Pharmaceutical Science. 2016 Mar; 6(3): 159-171.