Evaluation of the Pharmaceutical Quality of Different Brands of Ranitidine Tablets Manufactured in Bangladesh: A Pharmaceutical and Public Health Prospective.
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Date
2016-01
Authors
Sarker, Md Moklesur Rahman
Rashid, Md Salman
Raju, Ali Asghar
Rana, Masud
Karim, Mohammed Faisal Bin
Akter, Rehana
Howlader, Abu Nayem Md Al-Noman
Ming, Long Chiau
Ismail, Nahlah Elkudssiah
Journal Title
Journal ISSN
Volume Title
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Abstract
Drug counterfeiting and production of substandard drug is a global problem. Substandard or counterfeit drugs are threat for the effective treatment of diseases and highly worsen the quality of life of patients. This study was aimed to assess the pharmaceutical quality of ranitidine hydrochloride tablets manufactured in Bangladesh. Tablets were collected from different parts of Bangladesh and quality parameters were evaluated according to the United States Pharmacopoeia and the British Pharmacopoeial methods. The potency of tablets was measured spectrophotometrically. Weight variation and disintegration time were performed according to pharmaceutical monographs. Among 43 brands tested, 8 failed to comply with the USP specification (active ingredient: 90±10%) due to containing of less amount of ranitidine of which 6 brands were spurious and 2 were substandard in nature. Two brands did not comply with the specification for weight variation of tablets whereas all brands passed disintegration time test. The findings clearly demonstrate the production of substandard ranitidine tablets in Bangladesh. The drug control authority of Bangladesh should take effective steps to prevent the production of substandard drugs to secure public health.
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Keywords
Ranitidine, Spectrophotometric analysis, Disintegration time, Quality of drugs, Substandard and Counterfeit drugs, Spurious drugs, Bangladesh
Citation
Sarker Md Moklesur Rahman, Rashid Md Salman, Raju Ali Asghar, Rana Masud, Karim Mohammed Faisal Bin, Akter Rehana, Howlader Abu Nayem Md Al-Noman, Ming Long Chiau, Ismail Nahlah Elkudssiah. Evaluation of the Pharmaceutical Quality of Different Brands of Ranitidine Tablets Manufactured in Bangladesh: A Pharmaceutical and Public Health Prospective. Journal of Applied Pharmaceutical Science. 2016 Jan; 6(1): 55-61.