Positron emission tomography thyroid incidentaloma: Is it different in Indian subcontinent.
Loading...
Date
2016-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
BACKGROUND: Positron emission tomography (PET) forms an integral part in work‑up and follow‑up of various malignancies. With the
increased use of PET in oncology, finding of an incidental focal thyroid uptake (incidentaloma) is not unusual and presents a diagnostic
challenge. AIM: The aim of the following study is to evaluate the frequency and radio‑pathologic correlation of focal 18‑fluoro deoxyglucose
uptake (FDG) on PET within the thyroid from a large series. MATERIALS AND METHODS: Retrospective review of 37,000 consecutive patients
who underwent FDG‑PET at tertiary cancer center in India. Radiological, pathological, PET scan and follow‑up details were evaluated.
Statistical analyzes were carried out using Mann Whitney test and Pearson correlation. RESULTS: Abnormal thyroid uptake was seen in
78 (0.2%) patients. Nearly 61 (0.16%) scans had focal and 17 (0.04%) had diffuse FDG uptake. A total of 57 patients with focal uptake
were available for further evaluation. No further evaluation was done in 24 (42.1%) patients who had advanced index malignancy. Of the
remaining 33 patients 26 were benign and seven were a cause for concern (four primary thyroid cancers, one follicular neoplasm with
hurthle cell change and two metastatic cancers). There was no significant correlation in Standardized uptake value (SUV) max of benign
and malignant lesion (P = 0.5 on Mann Whitney) or size (r = 0.087 Pearson correlation co‑efficient P = 0.667). CONCLUSION: Incidence of
PET incidentaloma is low in this large cohort of Indian patients. Nearly 27% of focal incidentaloma were malignant. There was no correlation
between the SUVmax, size and malignancy.
Description
Keywords
Fine‑ needle aspiration cytology, positron emission tomographyPET CTcomputer tomography, thyroid carcinoma, thyroid incidentaloma, ultrasound of neck
Citation
Vaish R, Venkatesh R, Chaukar D A, Deshmukh A D, Purandare N C, D’cruz A K. Positron emission tomography thyroid incidentaloma: Is it different in Indian subcontinent. Indian Journal of Cancer. 2016 Jan-Mar; 53(1): 186-189.