Pap test accuracy and severity of squamous intraepithelial lesion.
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Date
2016-01
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Abstract
BACKGROUND: Cytology smears and guided biopsies are the most widely used diagnostic standards for cervical cancer (CC) screening in the
developing countries. AIM: To evaluate the performance of conventional cytology in estimating the presence and grade of cervical disease against
the reference standard of histopathology. SETTINGS AND DESIGN: After primary screening for CC, directed biopsies were performed and compared
with histopathology results. MATERIALS AND METHODS: Papanicolaou (Pap) smears and biopsies from 3194 women in the age group of 14‑98 years
were included. Cytology results were provided by doctors who performed the cervical biopsies. STATISTICAL ANALYSIS: The accuracy of Pap
smear was measured by sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) calculated using the statistical
analysis program PSPP 0.7.8. RESULTS: The sensitivity of conventional cytology (Pap smear) for women with low‑grade cervical intraepithelial
neoplasia or less serious lesions (CIN1‑) was 93% and specificity was 73%. The sensitivity and specificity of cytology for women with high‑grade
cervical intraepithelial neoplasia or cancer (CIN2+) was 64% and 84%, respectively. CONCLUSION: Cytology is a sufficiently sensitive test for
detection of cervical lesions and can be used as a primary testing tool to triage.
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Keywords
Cancer, cytology, uterine cervical diseases
Citation
Cobucci RNO, Maisonnette MJAS, Macêdo EJS, Santos Filho FC, Rodovalho PEF, Nóbrega MM, Gonçalves AKS. Pap test accuracy and severity of squamous intraepithelial lesion. Indian Journal of Cancer. 2016 Jan-Mar; 53(1): 74-76.