Hypofractionated radiotherapy for localized prostate cancer using three‑dimensional conformal radiotherapy technique: 3 years toxicity analysis.
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Date
2015-10
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Abstract
BACKGROUND: Hypofractionated radiotherapy in the radical treatment of localized prostate cancer has potential biological advantages relative to
conventional fractionation. We report prospectively collected toxicity data from a cohort of patients treated with a 3D conformal technique (3DCRT).
MATERIALS AND METHODS: 90 patients receiving curative intent hypofractionated radiotherapy with 57Gy in 19 daily fractions over 3.8 weeks
were evaluated prospectively for the development of radiation related toxicity over a 3 year period. RESULTS: All patients completed treatment.
Maximal acute toxicity experienced was 58.6, 10 and 1.1% for grade 1, 2 and 3 genitourinary (GU) toxicity respectively and 75.6, 9 and 0% for
gastrointestinal (GI) toxicity. For late toxicity the three year actuarial rates of grade 1, 2 and 3 GU and GI toxicity respectively were 47.3, 2.4 and
0%; and 40, 9.3 and 4.7%. There were no grade 4 or worse acute or late toxicities. 97.6% of evaluable patients remained free of biochemical
failure 36 months post radiotherapy. CONCLUSIONS: A 57Gy in 19 daily fraction radiotherapy schedule using 3D conformal radiotherapy for the
definitive treatment of localized prostate cancer has acceptable early and late toxicity.
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Keywords
Hypofractionation, prostate cancer, radiotherapy, toxicity
Citation
White R, Woolf D, Li S, Alonzi R, Osler P, Hoskin P, Hughes R. Hypofractionated radiotherapy for localized prostate cancer using three‑dimensional conformal radiotherapy technique: 3 years toxicity analysis. Indian Journal of Cancer. 2015 Oct-Dec; 52(4): 654-657.