Genetic diversity through human leukocyte antigen typing in end‑stage renal disease patients and prospective donors of North India.
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Date
2016-01
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Abstract
As the incidence of end-stage renal disease (ESRD) is rapidly increasing, the
demand for dialysis and transplantation has dramatically increased, which
has led to concerns about the availability and equitable allocation of kidneys
for transplantation. The distribution of HLA-A, B and DR alleles in 148 renal
transplant recipients and 191 live related prospective donors from 2009 to 2010
were analyzed. Allele frequencies and haplotype frequencies were calculated
in recipients and donors. The prospective donors were further analyzed on
the basis of their relationship to the patients and according to the sex ratio.
A significant female preponderance was noted in the prospective donor
population, most of whom were either siblings or parents of the recipients.
On the contrary, the recipient population predominantly comprised of males.
The most frequent HLA-A, HLA-B, HLA-DRB1 alleles in renal transplant
patients were HLA-A*11, A*02, A*01, A*24; HLA-B*35, B*40, B*44, B*15,
B*52, and HLA-DRB1*15, DRB1*07, DRB1*13, DRB1*11 respectively. The
most frequent HLA-A, HLA-B, HLA-DRB1 alleles in prospective donors were
HLA-A*02, A*11, A*33, A*24; HLA-B*35, B*44, B*40, B*15 and HLA-DRB1*15,
DRB1*07, DRB1*11, DRB1*13 respectively. A*11-B*35, A*02-DRB1*15, B*40-
DRB1*15 were the most common HLA A-B , HLA A-DR, HLA B-DR haplotypes
respectively in renal transplant patients, whereas, A*11-B*35, A*11-DRB1*15,
B*44-DRB1*07 were the most common haplotypes in renal donors. In three
locus haplotype, HLA-A*02-B*40-DRB1*15 was the most frequent haplotype
in patients, whereas, in prospective renal donors HLA-A*33-B*44-DRB1*07
was the most frequent haplotype.
Description
Keywords
Allele frequency, end‑stage renal disease, haplotype frequency
Citation
Chowdhry Mohit, Makroo Raj Nath, Kumar Manoj. Genetic diversity through human leukocyte antigen typing in end‑stage renal disease patients and prospective donors of North India. Indian Journal of Pathology & Microbiology. 2016 Jan-Mar 59(1): 59-62.