Prognostic impact of epidermal growth factor receptor on clear cell renal cell carcinoma: Does it change with different expression patterns.
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Date
2016-01
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Abstract
Introduction: The aim of this study was to assess whether epidermal
growth factor receptor (EGFR) overexpression was a significant prognostic
factor in clear cell renal cell carcinoma (CRCC) and whether its prognostic
significance was affected by immunohistochemical expression patterns.
Materials and Methods: Immunohistochemistry was performed on
100 cases of CRCC using an antibody against EGFR. Tumors were grouped
by nuclear grade (NG) as low‑NG (NG1, 2) or high NG (NG3, 4), and by
pathological stage as localized (pT1, 2), or locally invasive (pT3, 4). Clinical
disease was grouped by clinical stage as early stage (stage I, II), or late
stage (stage III, IV). Evaluation of the EGFR overexpression was based on
cytoplasmic (EGFRCyt), and membranous (EGFRMem) staining. Results: EGFRCyt
correlated with high NG (P = 0.001), lymphovascular invasion (P = 0.028),
regional lymph node involvement (P = 0.027), metastasis (P = 0.001), late
stage (P = 0.003), cancer‑specific death (P = 0.036), and was a predictor
for disease‑specific survival (P = 0.012) whereas EGFRMem correlated with
only local invasion (P = 0.021) and perirenal invasion (P = 0.009) and did not
show any correlation with cancer‑specific death or disease specific survival.
Conclusion: Our findings suggest that EGFR overexpression is an important
prognostic factor in CRCC, and its prognostic value differs significantly with
respect to the location of EGFR immunostaining. This prognostic difference may
give direction on the management and treatment of CRCC patients.
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Keywords
Clear cell renal cell carcinoma, epidermal growth factor receptor, prognosis, survival
Citation
Kankaya Duygu, Kiremitci Saba, Tulunay Ozden, Baltaci Sumer. Prognostic impact of epidermal growth factor receptor on clear cell renal cell carcinoma: Does it change with different expression patterns. Indian Journal of Pathology & Microbiology. 2016 Jan-Mar 59(1): 35-40.