Antimicrobial resistance trends in blood culture positive Salmonella Paratyphi A isolates from Pondicherry, India.
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Date
2016-04
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Abstract
Enteric fever is a public health problem with the upsurge in the occurrence of Salmonella isolates that are resistant to
ciprofloxacin. In this study, a total of 284 blood culture isolates of S. Paratyphi A were investigated. Of these isolates,
281 (98.9%) were nalidixic acid resistant. A high rate (6.3%) of high-level resistance (≥4 µg/mL) was found to
ciprofloxacin. The isolates with ciprofloxacin minimum inhibitory concentrations (MICs) of ≥12 µg/mL had 4 mutations,
2 mutations within the quinolone resistance-determining region of gyrA and 2 mutations also in parC. According to
the Clinical Laboratory Standards Institute 2012 MIC breakpoints, 75.0% of isolates were resistant to ciprofloxacin.
Finally, 3 major pulsed-field gel electrophoresis patterns were observed among the S. Paratyphi A isolates. The spread
of fluoroquinolone resistant S. Paratyphi A necessitates a change toward ‘evidence-based’ treatment for enteric fever.
The research provides a perspective on the increasing prevalence of antimicrobial resistant S. Paratyphi A isolates in this
region of India.
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Keywords
Blood culture, ciprofloxacin, gyrA, multi-drug resistant, Salmonella Paratyphi A
Citation
Menezes G A, Harish B N, Khan M A, Goessens W, Hays J P. Antimicrobial resistance trends in blood culture positive Salmonella Paratyphi A isolates from Pondicherry, India. Indian Journal of Medical Microbiology. 2016 Apr-June; 34(2): 222-227.