Carcinoma of buccal mucosa: A site specific clinical audit.
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Date
2015-10
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Abstract
BACKGROUND: Carcinoma of buccal mucosa is the most common cancer of the oral cavity in India. Treatment of oral cancer poses unique reconstructive
challenges, owing to the dynamic architecture of the oral cavity. Despite current progress in various treatment modalities, over the past 50 years
survival rates have not improved drastically. Although, philosophy on treatment of buccal mucosa carcinoma remains well‑established, due to the
relative paucity of reported data, retrospective reviews of institutional experiences are of prime importance. This study provides a detailed insight on
this site specific cancer of the oral cavity in the Indian population. AIM: The aim of this study is to analyze our experience with the management of
carcinoma of buccal mucosa; associated clinical presentation, outcomes and prognostic factors. SETTINGS AND DESIGN: A retrospective chart review
was performed of all cases of primary buccal mucosa carcinoma treated surgically between years 2008 and 2012 in SDM Craniofacial Unit, Karnataka,
India. MATERIALS AND METHODS: All cases were analyzed based on patient characteristics, clinical presentation, surgical and adjuvant therapy
rendered and treatment outcomes. A retrospective chart review was carried out using the hospital’s data base for the same. STATISTICAL ANALYSIS
USED: Kaplan‑Meier methods were used for analyzing disease free survival (DFS). Univariate analysis of prognostic factors was performed with log
rank test. RESULTS: The significant variables in univariate analysis were: Overall stage, T‑stage (T1/T2 vs. T3/T4) and nodal status (N0 vs. N+). We
found that staging, tumor size and nodal status were significant prognostic factors for DFS. CONCLUSION: The strong influence of overall disease
stage, tumor size, nodal status, final histopathological report and habits of tobacco/betel quid chewing, on prognosis; emphasizes the importance
of early diagnosis and prevention of carcinoma of buccal mucosa in the Indian population.
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Keywords
Buccal mucosa carcinoma, disease free survival, prognostic factors, T‑stage, N‑stage
Citation
Singhania V, Jayade B V, Anehosur V, Gopalkrishnan K, Kumar N. Carcinoma of buccal mucosa: A site specific clinical audit. Indian Journal of Cancer. 2015 Oct-Dec; 52(4): 605-610.