Hepatitis B Seroconversion after Vaccination in Infants in Rural and Urban Areas of Rawalpindi, Pakistan.
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Date
2015
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Abstract
Purpose: This study was designed to evaluate the immunogenicity of hepatitis B vaccine in infants
of rural and urban Pakistan and to find out the vaccine efficacy.
Methods: A sample of 400 subjects was taken by simple random method from the rural and urban
areas (200 from Rural and 200 from urban areas) of Rawalpindi District Pakistan. The serum
samples were analyzed by Enzyme Linked Immunosorbant assay (ELISA) for the quantitative
determination of antiHBs antibodies.
Results: As 88 (22%) infants out of the total 400 were found to be seropositive at baseline. The
post vaccination results showed that about 15 (7.53%) of infants had inadequate levels of
antibodies (i.e. <10 IU/L). Overall 92.46% infants showed a positive response to the vaccine. The
females showed higher titers of antiHBs against vaccination as compared to that of males. Infants of urban areas showed higher titers as compared to that of rural areas.
Conclusion: Our results reinforces that the Hepatitis B vaccine has a good tolerability and is highly
immunogenic among infants. It is recommended that serosurvey of HBsAg and vaccine coverage at
country level should be done.
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Keywords
Enzyme-linked immunosorbant assay, immunogenicity, hepatitis B, hepatitis B vaccine engerix (TM)-B
Citation
Perveen Irum , Raza Muhammad A, Sehar Shama, Zaidi Syed Sohail Zahoor, Ahmed Safia. Hepatitis B Seroconversion after Vaccination in Infants in Rural and Urban Areas of Rawalpindi, Pakistan. British Journal of Medicine and Medical Research. 2015; 5(12): 1557-1561.