Gastrointestinal Stromal Tumors: Experience from a Single Surgical Unit.
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Date
2015
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Abstract
Background: Gastrointestinal stromal tumors (GISTs) are rare tumors, but comprise the most
common mesenchymal neoplasms of the gastrointestinal (GI) tract. We report a clinical series of
abdominal GIST and discuss the diagnosis and management in Indian patients.
Case Series: The data on demographic profile, clinical presentation and management of 12 cases
of GIST from a single surgical unit in the last seven years were studied retrospectively.
Preoperatively, ultrasonographic and computerized tomographic scans of the abdomen were the
main investigations used for evaluation; the others being upper gastrointestinal endoscopy and
X-ray of the chest. Histopathological examination and immunohistochemical evaluation were used
to confirm the diagnosis.
Results: The mean age at presentation was 47.9 years (range 35 – 70 years). Mean duration of symptoms was of 5 months (range 10 days–2 years). While all 12 patients presented with
abdominal pain, 10 complained of abdominal lump. Two patients complained of vomiting and 1 of
upper GI bleed. All patients were operated. In 7 cases, the GIST was arising from the ileum, 3
from the stomach and 2 from the mesentery. Nine cases had low grade benign tumors and 3 had
malignancy.
Conclusion: Abdominal pain and lump are the most common clinical symptoms of abdominal
GIST. Vomiting, upper GI bleeding and weight loss are among the other important symptoms.
Most of the tumors are benign and surgical resection remains the mainstay of treatment.
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Keywords
Gastrointestinal stromal tumors, imatinib, CD 117, interstitial cells of cajal
Citation
Kumar Satendra, Bhartiya Satyanam Kumar, Basu Somprakas, Kumar Mohan, Shukla Vijay Kumar. Gastroi ntestinal Stromal Tumors: Experience from a Single Surgical Unit. British Journal of Medicine and Medical Research. 2015; 5(10): 1280-1286.