Biochemical and Histopathological Studies on the Effect of Raw and Cooked Tetracarpidium Conophorum on Male Albino Rats.
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Date
2015
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Abstract
Aim: This study is mainly aimed at investigating the study the toxic effects of raw and cooked
Tetracarpidium conophorum nut taken as snacks in Nigeria.
Study Design: Both biochemical and histopathological effects the raw (RTC) and cooked (CTC)
Tetracarpidium conophorum of different diet formulation were carried out following 30 days period
of oral feeding.
Methodology: Rats were divided into six groups of five rats each. Each feed and walnut was
weighed and mixed in the ratio of 1:1 before administration. Group A: Normal animal feed, Group
B: Mixture of animal feed and cooked nut (ratio of 1:1). Group C: Mixture of animal feed and the raw nut (ratio of 1:1), Group D: 100% of the cooked nut, Group E: 100% of the raw nut while Group
F: Mixture of raw nut and cooked (ratio of 1:1).
Results: Result showed that the aspartate amino transferase activity of group E and F (100% RTC
and 50% RTC+50%CTC) respectively were significantly higher (P<0.05) than that of the control
group (Group A). Alanine amino transferase activity of group B, E and F (50% feed + 50% CTC,
100% RTC and 50% CTC + 50% RTC respectively) were significantly higher (p<0.05) than that of
the group A (normal group). The ALP levels of group D (100% CTC) recorded a significant
increase (p<0.05) when compared with that of the control. The urea concentration of group F was
significantly higher (p<0.05) than that of the control group while there was no significant difference
(p>0.05) between the creatinine concentration of that of test groups and the control.
Histopathological results showed mild to severe changes in the liver of all the test groups.
However, no such changes were observed in the kidney of the test groups.
Conclusion: The results seem to suggest evidence of toxicity especially for RTC, indicating that
cooking of the nut might have reduced the level of toxicity.
Description
Keywords
Tetracarpidium conophorum, lobular architecture, inflammation, Histopathology, Creatinine, Alkaline phosphatase
Citation
Apeh V O, Amoke C O, Anaduaka E.G, Ohayi S A M, Egba S I, Agu C V, Uzoegwu P N. Biochemical and Histopathological Studies on the Effect of Raw and Cooked Tetracarpidium Conophorum on Male Albino Rats. British Journal of Medicine and Medical Research. 2015; 5(8): 1024-1033.