Reversible Acute Renal Failure in a Elderly Patient with Minimal Change Disease: A Case Report.
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Date
2015
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Abstract
Introduction: Minimal change disease is a histopathological lesion of the kidneys most commonly
associated with nephrotic syndrome. Three pathophysiological mechanisms have been proposed to
explain this syndrome: Nephrosarca (severe edema of the kidney), presence of acute tubular
necrosis and decreased of glomerular filtration rate.
Presentation of Case: We present a 69years old patient with minimal change disease presented
with severe renal dysfunction, dyspnoea, oedema of the lower extremities and weight gain of 10kg
the month prior to admission. Renal function did not improve despite excess fluid removal with
hemodialysis. Renal biopsy did not show significant interstitial Oedema but showed signs of tubular
damage and mild atherosclerosis. Renal function returned with remission of proteinuria following
administration of corticosteroid therapy.
Conclusion: Our case does not support the nephrosarca hypothesis but the presence of acute
tubular necrosis and decreased of glomerular filtration rate theories cannot be excluded.
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Keywords
Acute renal failure, hemodialysis, interstitial Oedema, minimal change disease, nephrotic syndrome
Citation
Chelioti Eleni, Papalexandrou Alexia , Efthymiou Evdokia, Tsilivigkou Maria. Reversible Acute Renal Failure in a Elderly Patient with Minimal Change Disease: A Case Report. British Journal of Medicine and Medical Research. 2015; 5(6): 836-841.