Impaired Fasting Glucose & 8-Iso- Prostaglandin F2a in Diabetes Disease Progression.
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Date
2014-11-21
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Abstract
Aims: The objective of the present study was to evaluate the changes of 8-
isoprostaglandin F2α and other markers of oxidative stress with impaired fasting glucose
when compared to non-diabetic control participants.
Methodology: This is a cross-sectional study, conducted at Charles Sturt University,
Albury, NSW, Australia and included 428 participants (female: male, 247:181) participants
attending the Diabetes Complications Clinic in the School of Community Health for the
period between January 2011 to October 2012.
Results: Urinary 8-isoprostaglandin F2α was significantly greater in the impaired fasting
glucose group (1.4±1.3ng/ml) compared to control group (0.68±0.5ng/ml, P= .05). The
increase in urinary 8-isoprostaglandin F2α was associated with a significant elevation in
serum total cholesterol (4.7±1.1mol/L, P= .04) and a significant reduction in high density
lipoprotein cholesterol (1.4±0.4mmol/L, P= .02) in the impaired fasting glucose group
compared to the control group. A significant negative correlation was noted between
urinary 8-isoprostaglandin F2α and high-density lipoprotein cholesterol among all the
participants included in this study (P= .05). Conclusions: The current study proves the importance of measuring markers of oxidative
stress, expressed by urinary 8-isoprostaglandin F2α and serum lipids in managing cases of
impaired fasting glucose and suggests a useful biomarker for assessing disease
progression and/or remission, especially in the prediabetic state.
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Keywords
Oxidative stress, impaired fasting glucose, 8-isoprostaglandin F2α, serum lipids
Citation
Jelinek Herbert F,Jamil Dina A, Aubaidy Hayder A Al. Impaired Fasting Glucose & 8-Iso- Prostaglandin F2a in Diabetes Disease Progression. British Journal of Medicine and Medical Research. 2014 Nov; 4(33): 5229-5237.