A Clinical Study of Cardiovascular Dysfunction in Patients of Cirrhosis of Liver.
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Date
2016-01
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Abstract
Background: Cirrhosis is a very common ailment in India mostly caused by alcoholism, viral hepatitis and malnutrition.
The clinical picture of patients with cirrhosis is dominated by the classical complications such as ascites, bleeding from
esophageal varices, portal hypertension and encephalopathy. Cardiovascular abnormalities have been reported by
several investigators. Methods: It is a cross sectional study done on 60 patients admitted to NIMS Medical College, Jaipur
between Jan. 2013 to Dec. 2014. USG of liver was done by GE Voluson promachine with probe frequency of 3.5 MHz
and high frequency of 7-10 MHz for detection of cirrhosis and ascites with special reference to caudate lobe, portal vein
and spleen. ANOVA with post hocTukey HSD was used for analysis of continuous variables whereas Chi-square test was
used for nominal/ categorical variables. p value < 0.05 was taken as significant. Results: Diastolic dysfunction is
measured by E/A ratio was prevalent LVED diameter, IV septal thickness, left ventricular posterior wall thickness were
proportional to severity of liver cirrhosis. Electro physiologically, 38.33% patients of cirrhotic liver patients had prolonged
QTc interval. Here, as far as cardiac abnormality were considered, we found QTc prolongation more in severe degree of
cirrhosis MELD score III (7 out of 10) 70%, than moderate (40%) MELD score II and mild (20%) MELD score I of cardiac
QTc prolongation. Conclusion: Diastolic dysfunction is a major criteria of cirrhotic cardiomyopathy which can be
diagnosed by electro and echo cardiography
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Keywords
Cardiovascular, Cardiomyopathy, Cirrhosis, Diastolic dysfunction
Citation
Patil Shweta, Lal Bajrang, Pandey Manju, Haldia S S, Rishi J P. A Clinical Study of Cardiovascular Dysfunction in Patients of Cirrhosis of Liver. Annals of International Medical and Dental Research. 2016 Jan-Feb; 2(1): 212-215.