Effective High Dose Multi-Drug Treatment Regimen Favours Event Free Survival Rate in DCMP Patients.
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Date
2016-01
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Abstract
Background: To study the effect of multidrug treatment regimen in the patient of DCMP (Dilated cardiomyopathy)
compared to single drug/ low dose multi drug regimen. Methods: A total of 40 patients diagnosed with DCMP (both
ischemic and non-ischemic) in the last 5 years attending to Cardiology OPD/ Inpatients in National Institute of Medical
sciences, Jaipur were enrolled in the study. Out of 40 patients, 20 were kept on routine treatment regimens like
diuretics, beta-blockers, angiotensinogen converting enzyme inhibitor/ Angiotensin receptor blockers (ACEI/ARB), either
of them or all three of them in low dose. The other 20 patients were started on mineralocorticoid receptor antagonists
(MRA’s), beta-blockers, ACEI all together with gradual increments of doses to a higher level. Both these groups were
followed for 2 years and we found that patient groups with effective high dose multi drug regimen has good event free
survival rate compared to traditional single drug /low dose multiple regimen. Tests of statistical significance were done
using Chi-square Test. Results: Out of 20 patients in normal (routine treatment regimen) 12 patients presented with
congestive cardiac failure (CCF) ,15 with dyselectrolemia ,10 with hypotensive episodes and 6 deaths were seen
compared to 5 patients with CCF, 5 with dyselectrolemia, 8 with hypotension and 2 deaths were seen in high dose multi
drug regimen. Out of this episodes of CCF (p=0.002), dyselectrolemia (p=0.001) are statistically significant.
Conclusion: High dose MDR is preferable for event free survival rate in patients of DCMP.
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Keywords
Eplerenone, Dilated Cardiomyopathy, Multi drug regimen
Citation
Syed Thabish, Lal Bajrang, Ahir Dilip, Rishi J P, Shah Moxit. Effective High Dose Multi-Drug Treatment Regimen Favours Event Free Survival Rate in DCMP Patients. Annals of International Medical and Dental Research. 2016 Jan-Feb; 2(1): 208-211.