Antidiabetic Activity of Hydroalcoholic Extracts of Nardostachys jatamansi in Alloxan-induced Diabetic Rats.
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Date
2014-10-01
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Abstract
A review of literature indicates that diabetes mellitus was fairly well known and well
conceived as an entity in India with complications like angiopathy, retinopathy,
nephropathy, and causing neurological disorders. The antidiabetic study was carried out
to estimate the anti hyperglycemic potential of Nardostachys Jatamansi rhizome’s hydro
alcoholic extracts in alloxan induced diabetic rats over a period of two weeks. The
hydroalcoholic extract HAE1 at a dose (500mg/kg) exhibited significant
antihyperglycemic activity than extract HAE2 at a dose (500mg/kg) in diabetic rats. The hydroalcoholic extracts showed improvement in different parameters associated with
diabetes, like body weight, lipid profile and biochemical parameters. Extracts also
showed improvement in regeneration of β-cells of pancreas in diabetic rats.
Histopathological studies strengthen the healing of pancreas by hydro alcoholic extracts
(HAE1& HAE2) of Nardostachys Jatamansi, as a probable mechanism of their ant
diabetic activity.
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Keywords
Nardostachys jatamansi, diabetes mellitus, alloxan, hypoglycemic effect, hydroalcoholic extract
Citation
Aleem M A, Asad B Syed , Mohammed Tasneem, Khan Riyaz Ahmed, Ahmed M Farooq , Anjum A, Ibrahim M.Antidiabetic Activity of Hydroalcoholic Extracts of Nardostachys jatamansi in Alloxan-induced Diabetic Rats.British Journal of Medicine and Medical Research. 2014 Oct; 4(28): 4665--4673.