Effect of HIV Infection and Antiretroviral Therapy on Some Red Cell Enzyme Activities and Coagulation Parameters.
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Date
2014-08-01
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Abstract
Aim: To assess G-6-PD, Pyruvate kinase enzyme activity and some coagulation
parameters in HIV positive patients on antiretroviral treatment (ART) and those not on
antiretroviral treatments with varying durations of infection and Antiretroviral treatments.
Study Design: Case-control study
Place and Duration of Study: Nnamdi Azikiwe University Teaching Hospital Nnewi,
Nigeria from March to August 2013.
Methodology: We included 181 subjects; Sixty HIV patients on ART with infection and
ART duration of <1 – 5, >5 – 8 and >8 – 17 years; Sixty HIV patients not on ART with an
infection duration of <1 – 3, >3 – 6 and >6 – 11 years; and Sixty-one apparently healthy
individuals control. Glucose-6-Phosphate Dehydrogenase (G-6-PD) activity, Pyruvate
kinase (PK) activity, Activated Partial Thromboplastin time (APTT), Prothrombin time (PT), Platelet count (PLT)and Human Immunodeficiency virus (HIV) status were
determined.
Results: G-6-PD, APTT and PT, for ART and non-ART were significantly higher (P<
0.05) compared with those of control. G-6-PD and PT were significantly higher in ART
subjects when compared with non-ART (P<0.05). There was no significant difference in
Pyruvate kinase activity and platelet count (P>0.05). G-6-PD activity was significantly
higher in ART subjects with HIV duration of >8 – 17 years than<1 – 5 years and >5 – 8
years (P< 0.05), and also in non-ART subjects with HIV duration of>3 -6 years and>6 –
11 years compared with<1 – 3 years (P< 0.05). G-6-PD activity was significantly higher
in ART duration of>8 – 17 years compared to ART durations of >5 – 8 years and <1 – 5
years (P< 0.05).
Conclusion: This study identified a significant increase in G-6-PD activity in HIV patients
in proportion to the duration of infection and therapy while APTT and PT were
significantly prolonged in HIV patients implying a derangement in the intrinsic and
extrinsic coagulation pathways.
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Keywords
Pyruvate kinase, G-6-PD, HIV/AIDS, prothrombin time, activated partial thromboplastin time
Citation
Amilo G l, Okeke C O, lfeanyichukwu M O, Okeke A C, Ogenyi S l, Okoye J O. Effect of HIV Infection and Antiretroviral Therapy on Some Red Cell Enzyme Activities and Coagulation Parameters. British Journal of Medicine and Medical Research. 2014 Aug; 4(22): 3963-3974.