A Study on the Behaviour of Huntington’s Chorea Rat Models on Rotarod: Treated with Withanolide a and the Ethanolic Extract of Withania Somnifera.
Loading...
Date
2015-10
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Huntington’s disease (HD) is a fatal neurodegenerative disease named after George Summer
Huntington who first described the disorder in 1872. Huntington’s disease is associated with basal ganglia
degeneration which is called as the controlling center of extra pyramidal motor system that exerts an inhibitory
effect on cerebral motor cortex. This will filters the unwanted motor movements and so refines the motor
movements. Degeneration of neurons of basal ganglia reduces the inhibitory output and so leads to Huntington’s
disease. At present there is no cure for this disease and trials are going on to treat symptoms, slow the progress
of the disease and repairing the damages caused by disease. So there is a necessity to produce an animal model
of HD by using a neurotoxin kainic acid for research purpose. By this study we produced a simple and effective
rat model of HD which is more mimicking the human model of HD. We also analyzed the role of the extract of a
herbal plant Withania somnifera and its active principle withanolide A in preventing the nervous system of HD
rat models.
Results: The activity of the herbal drug was analyzed by using rotarod apparatus. Both the drug group animals
behaved normally in the rotarod against the lesion control animals and proved the efficacy of the drug employed.
Conclusion: Present days treatments are mostly given to reduce the progress of HD and to treat the symptoms.
Complete curation of HD is not up to the mark. But by taking these herbal drugs by daily basis we can prevent the
occurrence of HD as these drugs are very good in neuroprotection.
Description
Keywords
Huntington’s disease, Extrapyramidal motor system, Cerebral motor cortex, Rotarod, Withania somnifera, Withanolide A
Citation
Venkatramaniah C , Praba A Mary Antony. A Study on the Behaviour of Huntington’s Chorea Rat Models on Rotarod: Treated with Withanolide a and the Ethanolic Extract of Withania Somnifera. International Journal of Anatomy and Research. 2015 Oct-Dec; 3(4): 1510-1514.