Fertility Enhancing Potential of Mucuna pruriens Seeds in Female Sprague-Dawley Rats.
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Date
2014-06-01
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Abstract
Aims: To determine the effect of oral administration of methanolic seed extract of
Mucuna pruriens (M. pruriens) on oestrous cycle, ovulation, reproductive hormones and
oxidative stress in the ovary of cyclic Sprague-Dawley rats.
Design: Prospective animal study related to M. pruriens in reproductive area.
Place and Duration: Animal Facility of the Department of Anatomy, Faculty of Basic
Medical Sciences, College of Medicine of the University of Lagos, Nigeria between the
months of June 2012 and August, 2012.
Methodology: Forty female Sprague-Dawley rats with regular 4 days cycle averagely
weighing 145 g were used. Methanolic extract of M. pruriens was given orally at 50, 100
and 200 mg/kg body weight. Oestrous cycle was monitored daily. At the end of the
experiment animals were sacrificed by cervical dislocation. Oocytes were counted, blood
and ovaries were assayed for hormonal and biochemical studies respectively.
Results: Oestrous cycle remained unchanged in the treatment groups. Catalase and
superoxide dismutase levels were increased slightly compared to control. A dose
dependent increase in FSH and LH (p < 0.05 at 200 mg/kg) levels were observed with a increase in the number of oocytes released at ovulation compared to control.
Conclusion: M. pruriens seed extract has the potential to enhance fertility by increasing
serum levels of FSH and LH which in turn increases the number of oocytes released at
ovulation possibly through its antioxidant properties.
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Keywords
Mucuna pruriens, ovulation, oxidative stress markers, FSH, LH
Citation
Noah Ojo Temitope, Chinwe Gbotolorun Stella, Ayodele Oremosu Ademola. Fertility Enhancing Potential of Mucuna pruriens Seeds in Female Sprague-Dawley Rats. British Journal of Medicine and Medical Research. 2014 June; 4(16): 3148-3157.