Effect of Xylopia aethiopica, Fiscus mucuso and Anthocleista vogelli Extracts on Some Biochemical Parameters Following Ethanol-induced Toxicity.
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Date
2014-05-11
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Abstract
The objective of the study was to comparatively verify the effects of aqueous extracts of
three plants on some biochemical parameters following ethanol administration with a
view to ascertaining the role of the extracts in ameliorating ethanol toxicity.
A total of forty rats were divided into eight groups (n=5). Group A were control rats; Group B were administered with absolute ethanol; Group C were ethanol administered
rats treated with Xylopia aethiopica; Groups D were ethanol administered rats treated
with Fiscus mucuso, Group E were ethanol administered rats treated with Anthocleista
vogelli; Group F were normal rats administered orally with Xylopia aethiopica; Group G
were normal rats administered orally with Fiscus mucuso; Group H were normal rats
administered orally with Anthocleista vogelli. At the end of the experimental period, the
animals were sacrificed and serum was obtained for total protein, uric acid, creatinin,
urea, aspartate aminotrasferase (AST) and alanine aminotransferase (ALT) analysis
using respective research kits.
The result showed that Xylopia aethiopica had protective effect on the kidney as
compared with Fiscus mucuso and Anthocleista vogelli treated rats. Also, The AST and
ALT was lowered with the beginning of Xylopia aethiopia treatment. The total protein,
creatinin and urea were slightly (p>0.05) affected with ethanol, an effect which was
normalized with the beginning of extract treatment.
It can be concluded that Xylopia aethiopica had a better reno-protective and
hepatoprotective effect than Anthocleista vogelli and Fiscus mucuso extract as evident in
its ameliorative role on the biochemical profiles.
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Keywords
Ethanol, Xylopia aethiopica, Fiscus mucuso, Anthocleista vogelli
Citation
Ayoka A O, Okonji R E, Ofusori D A, Komolafe O A, Basmitale K D S, Fakunle J B. Effect of Xylopia aethiopica, Fiscus mucuso and Anthocleista vogelli Extracts on Some Biochemical Parameters Following Ethanol-induced Toxicity. British Journal of Medicine and Medical Research. 2014 May; 4(14): 2705-2712.