Inflamatory Changes in Laryngeal Mucosa in Rats Due to Acid, Nitrite and Pepsin Exposition.
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Date
2014-03-21
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Abstract
Smoking and alcoholism are risk factors for head and neck malignancies. Other possible
risk factors for squamous cell carcinomas (SCC) are gastroesophageal (GER) and
pharyngolaryngeal (PLR) refluxes. Objectives: Demonstrate the carcinogenic action of
hydrochloric acid on the laryngeal mucosa of Wistar rats, potentialized by pepsin,
associated with nitrate applied in the rat laryngeal mucosa, simulating the reflux of the
gastric contents to the laryngopharynx. Method: Eighty-two Wistar rats were divided in
seven groups and submitted to 2 or 3 weekly applications of hydrochloric acid, pepsin and
sodium nitrate to the laryngeal mucosa during 6 months. Results: No dysplasia, intraepithelial
neoplasia or invasive carcinomas were seen. Inflammatory changes were
observed in varying degrees. Discussion: Several authors demonstrated the cocarcinogenic
action of GERD, whose mucosal irritating agent is hydrochloric acid.
Conclusion: It is possible that GERD and PLR are co-carcinogenic due to the inflammatory
action of hydrochloric acid potentialized by pepsin.
Description
Keywords
Head and neck cancer, squamous cell carcinoma, gastroesophageal reflux, larynx, hydrochloric acid
Citation
Negro Andre Del, Tincani Alfio Jose, Araujo Marina Rachel, Altemani Albina Milani, Martins Antonio Santos, Andreollo Nelson Adami. Inflamatory Changes in Laryngeal Mucosa in Rats Due to Acid, Nitrite and Pepsin Exposition. British Journal of Medicine and Medical Research. 2014 Mar; 4(9): 1791-1801.