Association of Angiotensin-I-Converting Enzyme (ACE) Insertion/Deletion Gene Polymorphism with End Stage Renal Disease in Egyptian Patients.
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Date
2014-03-11
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Abstract
Angiotensin-I-converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been
associated with the genetic susceptibility to end stage renal disease (ESRD) in different
populations. ACE DD genotype and D allele are associated with ESRD as risk factors in
several studies. In this study, we investigated the association between ACE I/D gene
polymorphism and ESRD in the Egyptian patients. Frequencies of D allele and DD
genotype were significantly increased, while frequencies of I allele and ID genotype were
significantly decreased in the ESRD patients when compared with the control subjects
(P = .012, OR = 1.82, 95% CI = 1.139-2.915 for DD) and (P = .018, OR = 1.6, 95%
CI = 1.082-2.33 for D). In conclusion, ACE DD genotype and D allele are associated with
ESRD as risk factors for ESRD in the Egyptian population.
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Keywords
Angiotensin-I-converting enzyme (I/D) polymorphism, end stage renal disease
Citation
Abdel-Aziz A F, El-Saeed Afaf, El-Dahshan Khaled, Ebead Basma Al-Sayed. Association of Angiotensin-I-Converting Enzyme (ACE) Insertion/Deletion Gene Polymorphism with End Stage Renal Disease in Egyptian Patients. British Journal of Medicine and Medical Research. 2014 Mar; 4(8): 1763-1771.