Effect of Renin Angiotensin System [RAS] Blockade on Blood Glucose Levels in Prediabetic Hypertensive Patients.
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Date
2014-03-01
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Abstract
Introduction: Patients with hypertension have an increased prevalence of type II
diabetes mellitus and impaired glucose tolerance. Prevalence of prediabetes is
increasing worldwide and experts have projected that more than 470 million people will
have pre-diabetes by 2030. A proportion of 5-10% of people per year with pre-diabetes
will progress to diabetes, with the same proportion converting back to normoglycemia.
Blockade of Renin Angiotensin System [RAS] either by an Angiotensin converting
enzyme (ACE) inhibitor or an Angiotensin receptor blocker (ARB) would slow down the
progression of prediabetic state to diabetes.
Methods: This was an open labeled, prospective, observational cohort study and a total
of 71 prediabetic hypertensive patients who were prescribed either an ACE inhibitor or
ARB monotherapy were enrolled into the study. An oral Glucose Tolerance Test (GTT)
was done in all the patients at baseline, end of 6 months and end of 1 year of treatment
with RAS blockade.
Results: At the end of 1 year, out of cohort of 59 prediabetic hypertensive patients who
completed the study, 28.81% were in the Normal glucose tolerance (NGT) group,
23.72% developed diabetes whereas 47.45% remained prediabetic at the end of study
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Keywords
Prediabetic, renin angiotensin system blockade, systolic BP, Age, glucose tolerance test
Citation
Bondalapati Sowmya, Rao V Dharma, Rampure Dilip, Rao S Rama. Effect of Renin Angiotensin System [RAS] Blockade on Blood Glucose Levels in Prediabetic Hypertensive Patients. British Journal of Medicine and Medical Research. 2014 Mar; 4(7): 1494-1505.