Clinico-Demographic Analysis and Outcome of Childhood Thrombosis in a Pediatric Hematology-Oncology Unit: A single Center Experience.
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Date
2014-01-21
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Abstract
Aim of the study: Thrombosis is rare in childhood with limited studies. Our retrospective
study was designed to evaluate children with documented thrombotic events registered
in our pediatric hematology -oncology unit over the last 3 years as regards clinical
features, etiology, management and outcomes.
Methods: Among 963 newly registered, 30 patients (16 females and 14 males, median
age 4.5 years) with clinical and radiological evidence of thrombosis were identified. Data
collection included clinical presentation, identifiable risk factors, thrombophilia screening,
radiologic investigations, treatment and outcome.
Results: Age at first thrombotic event was higher for patients with secondary than
primary etiology (p=0.018). In 66.7% of patients, there was at least one identified risk for
thrombosis, and cancer chemotherapy was the most frequent etiology. Inherited
thrombophilia were proven in 13.3%. Secondary thrombophilia presented mostly with
neurological symptoms (70%) while inherited thrombophilias with purpura fulminans
(80%) (p=0.001). The recurrence was higher with primary (30%) compared to secondary thrombophilias (10%). Patients' outcome included neurologic deficit (26.7%), recurrence
(16.7%), amputation (6.7%) and death (16.7%).
Conclusion: Thrombosis secondary to an acquired risk factor occurred at older age,
commonly presented by central thrombosis with no significant difference between
primary and secondary thrombosis in the residual effects. Further studies are warranted
to determine proper duration of anticoagulant therapy to prevent recurrence.
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Keywords
Childhood, clinicodemographic, thrombosis, outcome, Egypt
Citation
Mokhtar Galila M, Matter Randa M, Ragab Iman A, Salah- Eldeen Nanies M. Clinico-Demographic Analysis and Outcome of Childhood Thrombosis in a Pediatric Hematology-Oncology Unit: A single Center Experience.British Journal of Medicine and Medical Research. 2014 Jan; 4(3): 873-882.