Prevalence of Subclinical Peripheral Neuropathy in Chronic Obstructive Pulmonary Disease.
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Date
2015-10
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Abstract
Background: Present study aimed to assess peripheral neuropathy in stable COPD patients, its prevalence, type and
distribution and correlate the changes with severity of COPD. Methods: Study comprised of 60 healthy adults and 60 stable
nonalcoholic and normo-glycemic COPD patients (30-70yrs) with no clinical symptoms and signs of neuropathy. Severity of
COPD was classified as per WHO GOLD criteria. Nerve conduction study of four motor and four sensory nerves of upper
and lower limb was done and parameters like distal latency, amplitude and conduction velocity was studied. Results: Study
revealed prolonged distal latency, reduced conduction velocity and reduced amplitude in COPD patients as compared to
controls. More number of nerves involved with increasing severity of disease. The observations revealed that demyelinating
motor and axonal sensory neuropathy can be seen in COPD patients and neuropathy occurred even in mild COPD patients.
Conclusion: Sensory polyneuropathy predominant in lower limb was present in majority of patients.
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Keywords
COPD, Peripheral neuropathy
Citation
Dave Lokendra, Srivastava Nishant, Chaturvedi Shivani, Dube T N, Dave Rashmi, Saxena Soniya. Prevalence of Subclinical Peripheral Neuropathy in Chronic Obstructive Pulmonary Disease. Annals of International Medical and Dental Research. 2015 Oct-Dec; 1(3): 199-204.