Comparative Study of Histo-Pathological Effects of Mercury on Cerebrum, Cerebellum and Hippocampus of Adult Albino Rats.
Loading...
Date
2015-04
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Previously it was thought that mercury sulphide in low dose shows good therapeutic effect without producing
toxic effects in the human beings. Symptoms like ataxia, speech impairment, visual field constriction, deafness, tremors,
mental retardation, coma and even death has been reported due to chronic use of this heavy metal. The aim of our present
study is to compare histopathological changes in different parts of brain, so that clinical symptoms following mercury
intoxication can be explained. Methods: Freshly prepared sterile solution of mercuric chloride in distilled water (0.33 mg/kg
body weight) was orally administered daily to total number of 30 adult albino rats (15 males and 15 females) for a month.
3mm thick sections were taken from cerebrum, cerebellum and hippocampus parts. These sections were processed and
then stained by haematoxylin & eosin to be observed in light microscope. Results: Histological pictures of all the three
areas were suggestive of multiple foci of necrosis with gliosis. Marked congestion of vessels with perivascular necrosis was
also noticed. Increased cellularity of granular layer and molecular layer in cerebellum and hippocampus were seen
respectively. Conclusion: The histopathological examination revealed that normal cytoarchitecture of all the three areas of
brain were distorted resulting in various neurological disorders.
Description
Keywords
Cerebellum, Cerebrum, Hippocampus, Histopathology, Mercury
Citation
Ranjan Brajesh, Husain S M Dawar, Kumar Kundan, Maheshwari Tarun Prakash. Comparative Study of Histo-Pathological Effects of Mercury on Cerebrum, Cerebellum and Hippocampus of Adult Albino Rats. Annals of International Medical and Dental Research. 2015 Apr-June; 1(1): 21-24.