Ampicillin and Gentamicin Are a Useful First-line Combination for the Management of Sepsis in Under-five Children at an Urban Hospital in Bangladesh.
Loading...
Date
2012-12
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The study evaluated the commonly-used drugs for the management of sepsis and their outcome
among under-five children. We evaluated the hospital-records of all paediatric sepsis patients (n=
183) in the intensive care unit (ICU) and longer-stay unit (LSU) of the Dhaka Hospital of icddr,b.
These records were collected from the hospital management system (SHEBA) during November
2009 to October 2010. A total of 183 under-five children with clinical sepsis were found during
the study period, and 14 (8%) of them were neonates. One hundred and eighty-one patients had
received a combination of injection ampicilin and injection gentamicin, and two patients had received
the combination of injection ceftriaxone and injection gentamicin. Only 46 (25%) patients
required a change of antibiotics to the combination of intravenous ceftriaxone plus gentamicin
after non-response of injection ampicilin and injection gentamicin combination; 7/181 (4%) patients
died who received injection ampicilin and injection gentamicin whereas none died among
the other two patients who received injection ceftriaxone and injection gentamicin (p=1.00). The
combination of injection ampicilin and injection gentamicin as the first-line antibiotics for the
management of sepsis in children even beyond the neonatal age is very effective, resulting in
lower mortality.
Description
Keywords
Antibiotics, Children, Diarrhoea, Infant, Sepsis, Bangladesh
Citation
Bibi Samira, Chisti Mohammod Jobayer, Akram Farhana, Pietroni Mark A C. Ampicillin and Gentamicin Are a Useful First-line Combination for the Management of Sepsis in Under-five Children at an Urban Hospital in Bangladesh. Journal of Health, Population and Nutrition. 2012 Dec; 30(4): 487-490.