Seropositivity of Toxoplasmosis in Antenatal Women with Bad Obstetric History in a Tertiary-care Hospital of Andhra Pradesh, India.
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Date
2012-03
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Abstract
Toxoplasmosis is a well-documented cause of bad obstetric history (BOH) and a major reason of congenitally-
acquired infection. The study was conducted to determine the seropositivity of toxoplasmosis in
women with BOH, attending the antenatal clinic of the Mamata General Hospital, Khammam, Andhra
Pradesh, India. The study subjects included 105 antenatal women with BOH and 105 antenatal women
who had previous normal deliveries. A serological evaluation was carried out to determine the presence of
Toxoplasma gondii-specific IgG and IgM antibodies, using commercial diagnostic kits, by the enzyme-linked
immunosorbent assay method. The seropositivity for Toxoplasma was 49.52% in the study group compared
to 12.38% in the control group. The difference in seropositivity was significant (p=0.00). The seroprevalence
gradually increased with advancing age. Abortion (51.92%) was the commonest form of pregnancy wastage,
followed by stillbirths (36.53%) and premature deliveries (7.69%). The seropositivity of toxoplasmosis
was significantly higher in the study group than that in the control group, and the seropositivity played an
important role in determining the foetal outcome. Considering the subclinical pattern of infection, routine
serological test is recommended for all pregnant women for both IgG and IgM antibodies.
Description
Keywords
Bad obstetric history, Case-control studies, Descriptive studies, Seroprevalence, Toxoplasma gondii, Toxoplasmosis, India
Citation
Sarkar Munmun Das, Anuradha B, Sharma Neelam, Roy Rabindra Nath. Seropositivity of Toxoplasmosis in Antenatal Women with Bad Obstetric History in a Tertiary-care Hospital of Andhra Pradesh, India. Journal of Health, Population and Nutrition. 2012 Mar; 30(1): 87-92.