Comparative clinical evaluation of Boerhavia diffusa root extract with standard Enalapril treatment in Canine chronic renal failure.
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Date
2015-07
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Abstract
Background: Complementing herbal drugs with conservative modern treatment could improve renal condition in canine chronic
renal failure (CRF). Objective: In this study, clinical evaluation of Boerhavia diffusa root extract was carried out in CRF in
dogs in comparison with standard enalapril. Materials and Methods: A total of 20 dogs of mixed breeds suffering from CRF
from 1 to 2 months were divided into two groups (n = 10) and treated as follows: Group I ‑ Enalapril at 0.5 mg/kg p.o. once
daily for 90 days + amoxicillin and cloxacillin at 25 mg/kg i.m. once daily for 1‑week; Group II ‑ B. diffusa root extract at
500 mg p.o per dog daily for 90 days. Both groups were maintained on a supportive fluid therapy. The data were analyzed
using paired t‑test and one‑way ANOVA followed by Dunnett’s post‑hoc test. Results: CRF caused a significant (P < 0.05)
increase in systolic and diastolic blood pressure, serum creatinine, urea nitrogen, sodium, potassium, phosphorus, urinary
protein, alkaline phosphatase (ALP), and glutamyl transferase (GGT). A significant (P < 0.05) decrease in hemoglobin
and total erythrocyte count (TEC) was also observed. Nephrosonography revealed indistinct corticomedullary junction,
altered renal architecture, hyper‑echoic cortex, medulla, and sunken kidneys. Both the treatments significantly (P < 0.05)
reduced systolic and diastolic blood pressure by day 30. Serum Creatinine, urea nitrogen, phosphorus, urinary protein,
ALP, and GGT showed significant (P < 0.05) reduction by day 60 in both the treatments. However, potassium levels
were normalized only by B. diffusa root extract treatment by day 30. Both the treatments failed to show a significant
improvement in nephrosonographic picture even after 90 days posttreatment. Conclusions: In conclusion, the efficacy of
B. diffusa root extract was comparable to standard enalapril treatment of CRF in dogs.
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Keywords
Boerhavia diffusa, chronic renal failure, dogs, enalapril, nephrosonography
Citation
Oburai Nethaji Lokeswar, Rao V Vaikunta, Bonath Ram Babu Naik. Comparative clinical evaluation of Boerhavia diffusa root extract with standard Enalapril treatment in Canine chronic renal failure. Journal of Ayurveda and Integrative Medicine. 2015 July-Sept; 6(3): 150-157.