Antitubercular Drug Resistance in Four Healthcare Facilities in North India.
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Date
2011-12
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Abstract
Tuberculosis (TB) is a major public-health problem in India, having the highest number of incident and
multidrug-resistant (MDR) TB cases. The study was carried out to appraise the prevalence of first-line anti-
TB drug resistance in Mycobacterium tuberculosis (MTB) and its patterns among different types of TB patients
from different settings in a province of North India. Of 3,704 clinical specimens, 345 (9.3%) were culturepositive,
and drug-susceptibility testing was carried out for 301 MTB strains. A high level of primary and
acquired drug resistance of MTB was observed in the region studied, with weighted mean of 10.5%
and 28.08%, 12.81% and 29.72%, 17.12% and 29.94%, 11.97% and 27.84%, and 10.74% and 23.54%
for rifampicin, isoniazid, streptomycin, ethambutol-resistant and MDR cases respectively. Drug resistance
was significantly higher in pulmonary (p=0.014) and acquired drug-resistant TB cases (p<0.001). Any drug
resistance (p=0.002) and MDR TB were significantly (p=0.009) associated with HIV-seropositive cases. An
urgent plan is needed to continuously monitor the transmission trends of drug-resistant strains, especially
MDR-TB strains, in the region.
Description
Keywords
Acquired immunodeficiency syndrome, Antitubercular drugs, Diabetes, Drug resistance, HIV, Tuberculosis, India
Citation
Gupta Anamika, Mathuria Jitendra Prasad, Singh Surya Kumar, Gulati Anil Kumar, Anupurba Shampa. Antitubercular Drug Resistance in Four Healthcare Facilities in North India. Journal of Health, Population and Nutrition. 2011 Dec; 29(6): 583-592.