Significance of Expression of PSP94 Isoforms in Etiology of Benign Prostatic Hyperplasia and Prostate Cancer.
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Date
2015-05
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Abstract
Background: Prostate Secretory Protein of 94 Amino Acids (PSP94) level is known to increase in benign prostatic hyperplasia (BPH) and decrease in prostate cancer (PCa). However, there has not been a consensus on the abundance and significance of the different isoforms of PSP94 during the development of BPH and PCa.
Methods: Benign and malignant prostate tissue was ascertained histologically. Biplex polymerase chain reaction (PCR) and real-time PCR were employed to quantitate the two isoforms, PSP94 (MSMB1) and PSP57 (MSMB2).
Results: Higher abundance of both MSMB1 and MSMB2 transcripts was observed in BPH as compared to PCa. Further, there was a strong positive correlation between the transcript levels of these isoforms, MSMB1 and MSMB2, in samples from both BPH and PCa patients.
Conclusions: PSP57 (MSMB2) transcript may not be involved in the development of BPH or PCa and could have a physiological role in prostate cells.
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Keywords
Benign Prostatic Hyperplasia, Prostate Cancer, PSP94 (MSMB1), PSP57 (MSMB2)
Citation
Mhatre Deepa R, Mahale Smita D, Dhabalia Jayesh V, Tongaonkar Hemant B, Fernandes Swendolyn C, Dandekar Sucheta P, Varadkar Anand M. Significance of Expression of PSP94 Isoforms in Etiology of Benign Prostatic Hyperplasia and Prostate Cancer. IJSS Journal of Surgery 2015 May-June; 1(3): 1-7.