The hypolipidemic activity of Ayurvedic medicine, Arogyavardhini vati in Triton WR-1339-induced hyperlipidemic rats: A comparison with fenofi brate.
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Date
2013-07
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Abstract
Background: Hyperlipidemia is a major risk factor of coronary heart disease. Currently available hypolipidemic drugs
have been associated with number of side effects. Arogyavardhini vati, an Ayurvedic polyherbal formulation has been
used for liver disorders. Therefore, present study was designed to evaluate the effect of Arogyavardhini vati in Triton
WR-1339-induced hyperlipidemia in rats. Objectives: Anti-hyperlipidemic activity evaluation of Arogyavardhini vati against
Triton WR-1339-induced hyperlipidemia in rats. Materials and Methods: Overnight fasted male Wistar rats (150-200 g) were
randomly divided into normal control group [4% Dimethyl Sulfoxide (DMSO), i.p.], positive control group (Triton WR-1339
in 4% DMSO, 400 mg/kg, i.p.), standard drug treated (fenofi brate 65 mg/kg, p.o. for 7 days after inducing hyperlipidemia)
and Arogyavardhini vati treated (50, 100, 200 mg/kg, p.o. for 7 days after inducing hyperlipidemia). Rat doses were
calculated by extrapolating the equivalent human dose (therapeutic dose, sub-maximum, and maximum dose). Serum total
cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein HDL, liver malondialdehyde (MDA), and
glutathione (GSH) levels were estimated at end of experiments. Results: Arogyavardhini vati signifi cantly decreased serum
cholesterol, triglyceride, LDL, and C-reactive protein (CRP) and signifi cantly increased serum HDL in a dose-dependent
manner. Decreased MDA and increased GSH levels in liver were observed at all doses of Arogyavardhini vati (50, 100,
200 mg/kg) and fenofi brate-treated groups when compared with Triton-treated group. Atherogenic Index (AI) level was
signifi cantly decreased in fenofi brate and Arogyavardhini vati (200 mg/kg) treated rats when compared with normal control.
Conclusion: Arogyavardhini vati, a traditionally used Ayurvedic medicine may be a useful therapy for hypercholesterolemia
through reducing oxidative stress (decreasing MDA and increasing GSH) and lipid levels.
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Keywords
Arogyavardhini vati, atherogenic index, hypolipidemia, oxidative stress, Triton WR-1339
Citation
Kumar Gajendra, Srivastava Amita, Sharma Surinder Kumar, Gupta Yogendra Kumar. The hypolipidemic activity of Ayurvedic medicine, Arogyavardhini vati in Triton WR-1339-induced hyperlipidemic rats: A comparison with fenofi brate. Journal of Ayurveda and Integrative Medicine. 2013 July-Sept; 4(3): 165-170.