Development of standard operating procedures of Habbe Shifa: A polyherbal Unani formulation.
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Date
2013-07
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Abstract
Background: Unani medicines are being used since antiquity. However, in spite of their effi cacy, they have been widely
criticized due to lack of standardization and poor quality presentation. For this reason, application of good manufacturing
practices and development of standard operating procedures (SOPs) in the manufacture of herbal medicines became an
essential tool to assure their quality. Objectives: Therefore, the objective of the study was to develop the SOP of Habbe
Shifa (HS) regarding the particle size (PS), binder, temperature of drying, and duration of drying. Materials and Methods: In
this study, 24 batches of HS were prepared according to the instructions given in formulary to develop SOP. Three particle
sizes (i.e., 80, 100, and 120 No. Mesh sieve), were taken for preparation of pills. Water and Samaghe Arabi (Gum Acacia
mucilage [GAM]) were used as binder for preparing the lubdi (mass) in different batches. Different temperature and duration
of drying were used to dry the pills in hot air oven to get satisfactory results. All the batches were assessed three times for
hardness, friability, and disintegration time and mean regarded as standard parameter value. Results and Conclusion: The
batch with 150 m PS (100 mesh sieve), 5% w/w GAM used as a binder, dried at 90°C for 120 min showed hardness
3.50 ± 0.00 kg/cm, friability 0.02 ± 0.003%, and disintegration time 25.00 ± 0.57 min, which showed most appropriate
result among all batches and considered as fi nal batch. Its SOP may be used for future reference which can help in setting
up regulatory limit to assure the quality of Unani medicines.
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Keywords
Binder, duration of drying, particle size, standard operating procedures, temperature of drying
Citation
Tarannum Asira, Shamsi Shariq, Zaman Roohi. Development of standard operating procedures of Habbe Shifa: A polyherbal Unani formulation. Journal of Ayurveda and Integrative Medicine. 2013 July-Sept; 4(3): 147-151.