Antiulcer activity of water soaked Glycine max L. grains in aspirin induced model of gastric ulcer in Wistar rats.
Loading...
Date
2013-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Introduction: Glycine max L. with Drakshasava, widely used by traditional healers as a formulation for the treatment of
peptic ulcer in rural northern Karnataka in India, appears to be effective as assessed by patients and in our previously
published research work of traditionally used formulation. Aim: The present study was undertaken to evaluate the safety and
effi cacy of the overnight water soaked G. max grains. This is one of the components of traditional formulation. The study,
approved by Institutional Animal Ethics Committee was carried out in male Wistar rats after assessing its toxicity in mice.
Materials and Methods: Four groups of rats (n = 6 in each group) were treated with aspirin 200 mg/kg oral. In addition to
aspirin control group received normal saline, standard group received 20 mg/kg omeprazole and 3rd and 4th group received
G. max 250 and 500 mg/kg, respectively. All treatments were administered orally every 24 h for 7 days. After 24 hours
fasting, on the 8th day stomach contents were aspirated under anesthesia to estimate free and total acidity. Stomachs
were opened along the greater curvature to calculate ulcer index and subjected to histopathology studies. Statistics: The
results were analyzed by one-way analysis of variance followed-by Dunnett’s post hoc test. P ≤0.05 was considered as
signifi cant. Results: The severity of aspirin induced ulceration was found signifi cantly (P < 0.05) decreased in test groups
compared with the control group. Free and total acidity was signifi cantly reduced in 500 mg/kg treated group, compared
with the control group and was inferior to omeprazole treated group. Conclusion: The grain of G. max was found to be
effective against aspirin induced ulcers.
Description
Keywords
Aspirin, free acidity, gastric ulcer, Glycine max, total acidity
Citation
Kumar Dushyant, Hegde H V, Patil P A, Roy Subarna, Kholkute S D. Antiulcer activity of water soaked Glycine max L. grains in aspirin induced model of gastric ulcer in Wistar rats. Journal of Ayurveda and Integrative Medicine. 2013 July-Sept; 4(3): 134-137.