Reproductive effects of lipid soluble components of Syzygium aromaticum flower bud in male mice.
Loading...
Date
2013-04
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: The flower buds of Syzygium aromaticum (clove) have been used in indigenous medicines for the treatment
of male sexual disorders in Indian subcontinent. Objective: To evaluate the effect of Syzygium aromaticum flower bud on
male reproduction, using Parkes (P) strain mice as animal model. Materials and Methods: Mice were orally administered
lipid soluble components of Syzygium aromaticum flower bud in doses of 15, 30, and 60 mg/kg body weight for 35 days,
and several male reproductive endpoints were evaluated. Results: Treatment with lower dose (15 mg) of Syzygium
increased the motility of sperm and stimulated the secretory activities of epididymis and seminal vesicle, while higher
doses (30 and 60 mg) had adverse effects on sperm dynamics of cauda epididymidis and on the secretory activities of
epididymis and seminal vesicle. Libido was not affected in treated males; however, a significant decrease in litter in females
sired by males treated with higher doses of Syzygium was recorded. Conclusion: Treatment with Syzygium aromaticum
flower bud causes dose‑dependent biphasic effect on male reproductive indices in P mice; lower dose of Syzygium appears
stimulatory, while the higher doses have adverse effect on male reproduction. The results suggest that the lower dose of
Syzygium may have androgenic effect, but further studies are needed to support this contention.
Description
Keywords
Biphasic effect, epididymis, fertility, seminal vesicle, Syzygium aromaticum
Citation
Mishra Raghav Kumar, Singh Shio Kumar. Reproductive effects of lipid soluble components of Syzygium aromaticum flower bud in male mice.Journal of Ayurveda and Integrative Medicine. 2013 Apr-June; 4(2): 94-98.