Analysis of repeated measurement data in the clinical trials.
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Date
2013-04
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Abstract
Statistics is an integral part of Clinical Trials. Elements of statistics span Clinical Trial design, data monitoring, analyses
and reporting. A solid understanding of statistical concepts by clinicians improves the comprehension and the resulting
quality of Clinical Trials. In biomedical research it has been seen that researcher frequently use t‑test and ANOVA to
compare means between the groups of interest irrespective of the nature of the data. In Clinical Trials we record the data
on the patients more than two times. In such a situation using the standard ANOVA procedures is not appropriate as it
does not consider dependencies between observations within subjects in the analysis. To deal with such types of study
data Repeated Measure ANOVA should be used. In this article the application of One‑way Repeated Measure ANOVA
has been demonstrated by using the software SPSS (Statistical Package for Social Sciences) Version 15.0 on the data
collected at four time points 0 day, 15th day, 30th day, and 45th day of multicentre clinical trial conducted on Pandu Roga
(~Iron Deficiency Anemia) with an Ayurvedic formulation Dhatrilauha.
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Keywords
Anemia, Ayurveda, bio‑statistics, clinical trials, repeated measure analysis of variance
Citation
Singh Vineeta, Rana Rakesh Kumar, Singhal Ritcha. Analysis of repeated measurement data in the clinical trials.Journal of Ayurveda and Integrative Medicine. 2013 Apr-June; 4(2): 77-81.