Adjunct therapy of Ayurvedic medicine with anti tubercular drugs on the therapeutic management of pulmonary tuberculosis.
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Date
2012-07
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Abstract
Background: Pulmonary tuberculosis (PTB) is an age old disease described in Vedic Medicine as ‘Yakshma’. Later on, in
Ayurveda it earned a prefi x and found way into mythology as ‘Rajayakshma’. After the discovery of streptomycin, the
therapeutic management of PTB received a major breakthrough. The treatment module changed remarkably with the
formulation of newer anti-tubercular drugs (ATD) with appreciable success. Recent resurgence of PTB in developed countries
like United States posed a threat to the medical community due to resistant strains. Consequently, WHO looked toward
traditional medicine. Literature reveals that Ayurvedic treatment of PTB was in vogue in India before the introduction of
ATD with limited success. Records show that 2766 patients of PTB were treated with Ayurvedic drugs in a tertiary care
hospital in Kolkata in the year 1933-1947. Objectives: To evaluate the toxicity reduction and early restoration by adjunct
therapy of Ayurvedic drugs by increasing the bio-availability of ATDs. Materials and Methods: In the present study,
treatment response of 99 patients treated with ATD as an adjunct with Aswagandha (Withania somnifera) and a multiherbal
formulation described in Chikitsa-sthana of Charaka samhita i.e. Chyawanprash were investigated. Hematological
profi le, sputum bacterial load count, immunoglobulin IgA and IgM, blood sugar, liver function test, serum creatinine were
the assessed parameters besides blood isoniazid and pyrazinamide, repeated after 28 days of treatment. Results: The
symptoms abated, body weight showed improvement, ESR values were normal, there was appreciable change in IgA and IgM
patterns and signifi cantly increased bioavailability of isoniazid and pyrazinamide were recorded. Conclusion: This innovative
clinical study coupled with empowered research may turn out to be promising in fi nding a solution for the treatment of PTB.
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Keywords
Adjunct therapy, anti-tubercular drugs, Ayurveda, tuberculosis
Citation
Debnath P K, Chattopadhyay Jaydeb, Mitra Achintya, Adhikari Anjan, Alam Mirza Samsur, Bandopadhyay S K, Hazra Jayram. Adjunct therapy of Ayurvedic medicine with anti tubercular drugs on the therapeutic management of pulmonary tuberculosis.Journal of Ayurveda and Integrative Medicine. 2012 July-Sept; 3(3): 141-149.